Wales' run to the semifinal has them facing off against Cristiano Ronaldo and Portugal, while the other side of the bracket has a Germany v. France matchup worthy of a final.
Iceland's surprising run to the quarterfinal has them matched up with the home nation on Sunday, but Saturday features a heavyweight battle between Italy and Germany.
Cristiano Ronaldo highlights the players available for the two opening quarterfinal matches, but there are a few other stars who could outproduce him.
The Round of 16 concludes Monday, beginning with a huge Italy v. Spain match that could go either way, followed by England v. Iceland, which isn't likely to be as close.
The knockout rounds begin Saturday, with Cristiano Ronaldo, Gareth Bale and Robert Lewandowski highlighting the upper-tier options.
The final group stage matches will be played Wednesday, which could be the last time we see Zlatan Ibrahimovic playing for Sweden.
Groups C and D finish up Tuesday, with Germany and Spain well positioned to take the top spots, but some potential squad rotation could open up fantasy rosters.
Group B finishes up Monday, with three teams in reach of finishing on top of the table before heading to the knockout rounds.
The final matches of Group A will be played at the same time Sunday, with France needing only a draw to finish first.
When Portugal are on the slate, the simple question is: do we fade Cristiano Ronaldo?
Zlatan Ibrahimovic is back in action Friday, but is he worth taking against the very strong Italy defense?
Two huge grudge matches highlight Thursday's three-game slate, though the other game of the day could produce the most fantasy points.
The host nation returns to action for Wednesday's three-game slate, with many fantasy owners likely flocking toward France's Dimitri Payet after his stunning opening game.
Cristiano Ronaldo highlights Tuesday's Euro action, but fantasy owners will need to find some other pieces to fit together with the Portuguese superstar.
There aren't many elite goal-scorers on Monday's slate, despite high profile teams like Belgium and Italy, so it will be vital to find players who can contribute with other stats.
Sunday's three-game slate has a number of high-profile players, including Bayern Munich teammates Robert Lewandowski and Thomas Muller.
The 2016 European Championship kicks off this weekend, and Chris Henne returns with his top picks for DFS contests.