This article is part of our Showdown/Single Game DFS Breakdown series.
The undefeated 49ers host the up-tempo Cardinals on Thursday night, a game with fairly low 42.5-point total but a significant 10.5-point spread in favor of San Francisco. Prior to last week's 31-9 loss to the Saints, the Cardinals had scored at least 26 points in three straight games, though they came against the Bengals, Falcons and Giants; not exactly a murderer's row of defenses. Struggling against the Saints isn't surprising given their strong defensive unit, one that isn't as good as the 49ers', which is why the total is low.
Meanwhile, the 49ers put up 51 points last weekend against Carolina, the fourth time this season they scored at least 31. Their implied team total of 26.5 comes against a Cardinals defense that's allowed at least 21 points in every game this season, including at least 27 in five of eight. Given the expected score, fantasy players are likely to focus more on San Francisco than Arizona, though the latter has a couple players who could be considered.
The two quarterbacks couldn't be much different, as the Cardinals use Kyler Murray ($9,800 DK, $15,000 FD) as a major component to their passing (duh) and running game. Murray's 36.5 pass attempts per game this season are the seventh-highest in the league among quarterbacks with more than two starts, while Jimmy Garoppolo ($10,400 DK, $15,500 FD) has 27 quarterbacks ahead of his 27.0 pass attempts per game. The volume is understandably not there for Garappolo, who has finished with fewer than